|
KMID : 1123920150290030223
|
|
Korean Journal of Oriental Physiology and Pathology
2015 Volume.29 No. 3 p.223 ~ p.229
|
|
|
Study on Pharmacological Activation as Cosmetic Material of Gentianae scabrae bunge Extract
|
|
Choi Hyung-Wook
In Myung-Hee
Mun Yeun-Ja
Lim Kyu-Sang
Woo Won-Hong
|
|
|
Abstract
|
|
|
In this study, we investigated the effect of ethanol extracts from Gentianae scabrae bunge (GSB) on the activities
of antioxidant, whitening and anti-inflammation. Viability of cells was measured by neutral red (NR) assay, and
inhibitory effects of GSB on melanin synthesis was determined the melanin production in B16F10 cells. The expression
level of matrix metalloproteinase-1 (MMP-1) in media was analyzed by ELISA kit, and nitric oxide (NO) production in
RAW264.7 cells was monitored by measuring the nitrite content in culture medium. GSB showed highly efficacy in
1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, and significantly reduced melanin synthesis in B16F10
cells. MMP-1 production in UVB-stimulated human dermal fibroblast (HDF) cells was inhibited by GSB treatments. NO
production was suppressed by the treatment of GSB in LPS-stimulated RAW264.7 cells. From this results, it was
indicated that GSB could be utilized as anti-aging and whitening cosmetic ingredients.
|
|
|
KEYWORD
|
|
|
Gentianae scabrae bunge, antioxidant, melanin, MMP-1, nitric oxide
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|